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Genómica computacional

We are interested at the interrelation between chromatin structure and the organization of genome transcription and genome replication. In this context, we have developed our own HMM-based method for classifying genomic regions into chromatin states.

Publicaciones sobre genómica computacional:

  1. Sequeira-Mendes J, Aragüez I, Peiró R, Mendez-Giraldez R, Zhang X, Jacobsen SE, Bastolla U, Gutierrez C. The Functional Topography of the Arabidopsis Genome Is Organized in a Reduced Number of Linear Motifs of Chromatin States. Plant Cell. 2014 Jun 16;26(6):2351-2366. [Epub ahead of print]

  2. Lombraña R, Almeida R, Revuelta I, Madeira S, Herranz G, Saiz N, Bastolla U, Gómez M. High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins. EMBO J. 2013 32:2631-44. [Pubmed]

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