Publications of the Centrosome Consortium


  1. I.G. Muñoz, H. Yébenes, M. Zhou, P. Mesa, M. Serna, A.Y. Park, E. Bragado-Nilsson, A. Beloso, G. de Cárcer, M. Malumbres, C. V. Robinson, J. M. Valpuesta* y G. Montoya* (2011) Crystal structure of the mammalian cytosolic chaperonin CCT in complex with tubulin Nature Structural Molecular Biology 18, 14-19. (selected by the "Faculty of 1000")

  2. García-Mayoral MF, Rodríguez-Crespo I, Bruix M. Structural models of DYNLL1 with interacting partners African Swine Fever Virus protein p54 and the postsynaptic scaffolding protein gephyrin. FEBS Lett.585, 53-57 (2011).

  3. Januschke J, Llamazares S, Reina J, Gonzalez C. Drosophila neuroblasts retain the daughter centrosome. (2011) Nat Commun, 2:243.

  4. H. Yébenes, P. Mesa, I. G. Muñoz, G. Montoya and J. M. Valpuesta (2011) "Chaperonins: two rings for folding" Trends Biochem. Sci. 6, 424-32. (cover of the issue).

  5. M. Rodríguez-Rodríguez, M. A. Treviño, D.V. Laurents, R. Arranz, J.M. Valpuesta, M. Rico, M. Bruix and M.A. Jiménez (2011) "Characterization of the structure and self recognition of the human centrosomal protein NA14: Implications for stability and function" Protein Engineering, Design, and Selection. Dec;24(12):883-92.

  6. M.F. García-Mayoral, R. Castaño, M.L. Fanarraga, J.C. Zabala, M. Rico, and M. Bruix. (2011) The solution structure of the N-terminal domain of human Tubulin Binding Cofactor C reveals a platform for the interaction with tubulin. PLOS One 6(10):e25912.

  7. P. Rapali, M.F. García-Mayoral, M. Martínez-Moreno, J. Boskovic, K. Tárnok, K. Schlett, J- Kardos, J.P. Albar, M. Bruix, L. Nyitray, and I. Rodríguez-Crespo. (2011) LC8 dynein light chain (DYNLL1) binds to the C-terminal domain of ATM-interacting protein (ATMIN/ASCIZ) and regulates its subcellular localization. BBRC 414(3):493-8.

  8. J. Merino-Gracia J, M.F. García-Mayoral, I. Rodríguez-Crespo. (2011) The association of viral proteins with host cell dynein components during virus infection. FEBS J. 278(17):2997-3011.

  9. Meunier S, Vernos I. (2011) K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly. Nat Cell Biol. Nov 13;13(12):1406-14.

  10. Vanneste D, Ferreira V, Vernos I. Chromokinesins: localization-dependent functions and regulation during cell division. Biochem Soc Trans. 2011 Oct;39(5):1154-60.

  11. M.Mazzorana, G. Montoya & G. Mortuza. The Centrosome: A Target for Cancer Therapy. Curr. Cancer Drug Targets. Jun;11(5):600-12. Review.

  12. G.S. Nido, R. Méndez, A. Pascual-García, D. Abia and U. Bastolla. (2012) Protein disorder in the centrosome correlates with complexity in cell types number. Mol. BioSystems 2012, Jan 1;8(1):353-67.

  13. 2010

  14. Sorzano CO, Bilbao-Castro JR, Shkolnisky Y, Alcorlo M, Melero R, Caffarena-Fernández G, Li M, Xu G, Marabini R, Carazo JM, A clustering approach to multireference alignment of single-particle projections in electron microscopy, J Struct. Biol. 2010, Aug;171(2):197-206.

  15. Sigworth FJ, Doerschuk PC, Carazo JM, Scheres SH. An introduction to maximum-likelihood methods in cryo-EM. Methods Enzymol. 2010;482:263-94.

  16. Ziebarth TD, Gonzalez-Soltero R, Makowska-Grzyska MM, Núñez-Ramírez R, Carazo JM, Kaguni LS., Dynamic effects of cofactors and DNA on the oligomeric state of human mitochondrial DNA helicase. J Biol Chem. 2010 May7;285(19):14639-47.

  17. G. Fernández-Miranda, I. Pérez de Castro, M. Carmena, C. Aguirre, Guillermo Montoya, W. C. Earnshaw and M. Malumbres.  Modulation of Aurora B function by SUMOylation.  J. Cell Science 2010 Aug 15;123(Pt 16):2823-33. Epub 2010 Jul 27.

  18. R. Sánchez, D. Pantoja-Uceda, J. Prieto3, T. Diercks, M. J. Marcaida, G. Montoya, R. Campos-Olivas and F. J. Blanco. Solution structure of human growth arrest and DNA damage 45&[alpha] (GADD45&[alpha]) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A. J.Biol.Chem 2010 Jul 16;285(29):22196-201.

  19. Treviño MA, Rodríguez-Rodríguez M, Correas I, Marcilla M, Albar JP, Rico M, Jiménez MA, Bruix M. NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation. BMC Biochem. 2010 Jan 28;11:7.

  20. García-Mayoral MF, Martínez-Moreno M, Albar JP, Rodríguez-Crespo I, Bruix M. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. FEBS J. 277, 2340-2350 (2010).

  21. García-Mayoral MF, Castaño R, Zabala JC, Santoro J, Rico M, Bruix M. (2010) 1H, 13C, and 15N NMR assignments of the N-terminal domain of human Tubulin Cofactor C. Biol. NMR Assign, 4, 219-221.

  22. Sardon T, Pache RA, Stein A, Molina H, Vernos I, Aloy P (2010) Uncovering new substrates for Aurora A kinase EMBO Rep. 12:977-84.

  23. Fanarraga ML, Bellido J, Jaén C, Villegas JC, Zabala JC, 2010 TBCD Links Centriologenesis, Spindle Microtubule Dynamics, and Midbody Abscission in Human Cells. PLoS ONE 5(1): e8846. doi:10.1371/journal.pone.0008846.

  24. Gonçalves J, Nolasco S, Nascimento R, Fanarraga ML, Zabala JC, Soares H. (2010). TBCCD1 a new centrosomal protein is required for centrosome and golgi apparatus positioning. EMBO Reports 11 (3): 194-200.

  25. Monica Lopez-Fanarraga, Gerardo Carranza, Raquel Castaño, Sofia Nolasco, J. Avila and J.C. Zabala. 2010. Non-denaturing electrophoresis as a tool to investigate tubulin complexes. In MICROTUBULES IN VITRO. Methods in Cell Biology 95:59-75

  26. Mónica López Fanarraga, Gerardo Carranza, Raquel Castaño, Victoria Jiménez, Juan Carlos Villegas and Juan Carlos Zabala. Emerging roles for tubulin folding cofactors at the centrosome. Communicative & Integrative Biology 3(4):306-8; July/August 2010. Landes Biosciences, USA. ISSN 1942-0889.

  27. Januschke J, Gonzalez C. The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. J Cell Biol. 2010 Mar 8;188(5):693-70.

  28. R. Méndez and U. Bastolla, Torsional Network Model: Normal modes in torsion angle space better correlate with conformation changes in proteins. Phys. Rev. Lett. 2010 228103.

  29. F. Teichert, J.Minning, U. Bastolla and M. Porto, High quality protein sequence alignment by combining structural profile prediction and profile alignment using SABERTOOTH. BMC Bioinformatics 2010, 11:251.

  30. A. Pascual-Garcia, D. Abia, R. Méndez, G.S. Nido and U. Bastolla, Quantifying the evolutionary divergence of protein structures: The role of function change and function conservation. Proteins. 2010 78:181-96.

  31. R. Méndez, M. Fritsche, M. Porto and U. Bastolla, "Mutation bias favors protein folding stability in the evolution of small populations." PLoS Comput Biol 6(5): e1000767 2010.

  32. S. Sammet, U. Bastolla and M. Porto, (2010) "Comparison of translation loads forstandard and alternative genetic codes." BMC Evol. Biol. 2010, 10:178.

  33. 2009

  34. Nogales-Cadenas R, Abascal F, Díez-Pérez J, Carazo JM, Pascual-Montano A. "CentrosomeDB: a human centrosomal proteins database." Nucleic Acids Res. (2009) Jan;37 (Database issue):D175-80. Epub 2008 Oct 29.

  35. Alberto Pascual-Garcia, David Abia, Angel R. Ortiz and Ugo Bastolla (2009) "Cross-over between discrete and continuous protein structure space: Insights into automatic classification and networks of protein structures. PLOS Comp. Biol., Mar;5(3):e1000331.

  36. Mónica López Fanarraga, Juan C Villegas, Gerardo Carranza, Raquel Castaño and Juan Carlos Zabala. (2009). "Regulation of microtubule number in amoeboid microglia by tubulin cofactor B." Exp. Cell Res. Nov 12.

  37. Teresa Sardon, Thomas Cottin, Jing Xu, Athanassios Giannis and Isabelle Vernos (2009) "Development and Biological Evaluation of a novel Aurora A Kinase inhibitor" ChemBioChem 10(3):464-78.

  38. M. Alvarado-Kristensson, M. J. Rodríguez, J. M. Valpuesta and A. C. Carrera (2009) "SADB kinases mediated gamma-tubulin phosporylation regulates centrosome duplication" Nat. Cell. Biol. 11, 1081-92.

  39. S. Hormeño, B. Ibarra, F. J. Chichón, K. Habermann, B. M. H. Lange, J. M. Valpuesta, J. L. Carrascosa and J. R. Arias-Gonzalez (2009) "Single centrosome manipulation reveals its electric charge and associated dynamic structure" Biophysical J. 97,1022-30.

  40. C.O.S. Sorzano, E. Recarte, M. Alcorlo, J.R. Bilbao-Castro, C. San-Martín, R. Marabini, J.M. Carazo. (2009) "Automatic particle selection from electron micrographs using machine learning techniques." Journal of Structural Biology, 167: 252-260

  41. C.O.S. Sorzano, C. Messaoudi, M. Eibauer, J.R. Bilbao-Castro, R. Hegerl, S. Nickell, S. Marco, J.M. Carazo. (2009) "Marker-free image registration of electron tomography tilt-series." BMC Bioinformatics, 10: 124

  42. C.O.S. Sorzano, A. Otero, E.M. Olmos, J.M. Carazo. (2009) "Error analysis in the determination of the electron microscopical contrast transfer function parameters from experimental power spectra." BMC Structural Biology, 9:18

  43. Iriarte Ruiz, C.O.S. Sorzano,  J. L. Rubio, J. M. Carazo, R. Marabini. (2009) "A theoretical model for EM-ML reconstruction algorithms applied to rotating PET scanners." Physics in Medicine and Biology, 54: 1909-1934

  44. S.H.W. Scheres, R.M. Melero, M. Valle & J.M. Carazo (2009) "Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization" Structure, 17, 1563-1572

  45. S. Nickell, F. Beck, S.H.W. Scheres, A. Korinek, F. Foerster, K. Lasker, O. Mihalache, N. Sun, I. Nagy, A. Sali, J.M. Plitzko, J.M. Carazo, M. Mann & W. Baumeister (2009) "New insights into the molecular architecture of the 26S proteasome" Proc. Natl. Acad. Sci. U S A, 106, 11943-11947

  46. S.H.W. Scheres, & J.M. Carazo (2009) "Introducing robustness to maximum likelihood refinement of electron microscopy data" Acta Cryst. D65, 672-678

  47. S.H.W. Scheres, M. Valle, P. Grob, E. Nogales & J.M. Carazo (2009) "Maximum likelihood refinement of electron microscopy data with normalization errors" J. Struc. Biol., 166, 234-240

  48. 2008

  49. J. Cuéllar, J. Martín-Benito, S. H.W. Scheres, R. Sousa, F. Moro, E. López-Viñas, P. Gómez-Puertas, A. Muga, J. L. Carrascosa and J. M. Valpuesta. (2008) "The structure of a CCT:Hsc70NBD complex suggests a mechanism for Hsp70 delivery of substrates to the chaperonin" Nat. Struct. Mol. Biol. 15, 858-864. (selected by the "Faculty of 1000").

  50. Scheres SH, Núñez-Ramírez R, Sorzano CO, Carazo JM, Marabini R. (2008) Image processing for electron microscopy single-particle analysis using XMIPP. Nat Protoc. 3(6):977-90.

  51. J. Avila, H. Soares, M. L. Fanarraga and J.C. Zabala. (2008). Isolation of Microtubules and Microtubule Proteins. Current Protocols in Cell Biology. Unit 3.29.

  52. IG. Muñoz, Francisco J. Blanco, Guillermo Montoya (2008) On the relevance of defining protein structures in cancer research. Clin. Transl. Oncol. Apr;10(4):204-12. Review.

  53. Pérez de Castro I, de Cárcer G, Montoya G, Malumbres M. (2008) Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr Opin Pharmacol. Aug;8(4):375-83

  54. F. Abascal, P. Carmona-Saez, JM Carazo and A. Pascual-Montano. (2008) ChIPCodis: Mining complex regulatory systems in yeast by concurrent enrichment analysis of Chip-on-chip data. Bioinformatics. May 1;24(9):1208-9. 

  55. S.H.W. Scheres, G.T. Herman & J.M. Carazo. (2008) "Exploring the conformational flexibility of macromolecular machines". Mathematical Methods in Biomedical Imaging and Intensity-Modulated Radiation Therapy (IMRT).

  56. Eliscovich C., Peset I., Vernos I. and Mendez R. Localized CPE-mediated translation controls meiotic chromosome segregation Nature Cell Biology Jul;10(7):858-65. 

  57. Jan W. Vos, Laurent Pieuchot, Jean-Luc Evrard, Natacha Janski, Marc Bergdoll, Dryas de Ronde, Laurent-H. Perez, Teresa Sardon, Isabelle Vernos and Anne-Catherine Schmit (2008) The Plant TPX2 protein controls pro-spindle assembly before nuclear envelope breakdown Plant Cell 20(10):2783-97

  58. Teresa Sardon, Isabel Peset, Boryana Petrova and Isabelle Vernos (2008) Dissecting the role of Aurora a during spindle assembly EMBO J 27(19):2567-79

  59. Peset I and Vernos I. (2008) The TACC family of proteins: TACC-ling microtubule dynamics and centrosome function (2008) Trends in Cell Biology 18(8):379-88

  60. Castellanos, E.; Dominguez, P.; Gonzalez, C. (2008) Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Current Biology, Volume: 18, Issue: 16, 1209-1214 I.F.: 10.539.

  61. Gonzalez, C. (2008) Centrosome function during stem cell division: the devil is in the details Current Opinion in Cell Biology, Volume: 20, Issue: 6, 694-698 IF: 13.444

  62. Januschke, J.; Gonzalez, C. (2008) Drosophila asymmetric division, polarity and cancer Oncogene, Volume: 27, Issue: 55, 6994-7002 I.F.: 6.44

  63. 2007

  64. B. Garcia-Ãlvarez, G de Carcer, S. Ibañez E. Bragado-Nilsson & G. Montoya (2007) Molecular and Structural Basis of Plk1 substrate recognition. Implications in centrosome localization. Proc. Natl. Acad. Sci . USA 27;104(9):3107-12. IF 9.643

  65. Kiel, C., Foglierini, M., Kuemmerer, N., Beltrao, P. & Serrano, L. A genome-wide Ras-effector interaction network. J Mol Biol 370, 1020-32 (2007). IF 4.890

  66. Kiel, C. & Serrano, L. Prediction of Ras-effector interactions using position energy matrices. Bioinformatics 23, 2226-30 (2007). IF 4.894

  67. Kolsch, V., Seher, T., Fernandez-Ballester, G. J., Serrano, L. & Leptin, M. Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2. Science 315, 384-6 (2007). IF 30.028

  68. Pey, A. L., Stricher, F., Serrano, L. & Martinez, A. (2007) Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases. Am J Hum Genet 81, 1006-24. IF 12.629

  69. Szczepek, M. et al Serrano L. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol 25, 786-93 (2007). IF 22.672

  70. S.H.W. Scheres, R. Nuñez-Ramirez, Y. Gomez-Llorente, C. San Martin, P.P.B. Eggermont & J.M. Carazo. (2007) "Modelling experimental image formation for likelihood-based classification of electron microscopy data". Structure, 15, 1167-1177. IF 5.738

  71. Rebollo,E., Sampaio,P., Januschke,J., Llamazares,S., & Gonzalez, C. (2007). Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. Developmental. Cell 12, 467-474. IF 13.523

  72. Varmark,H., LlamazaresS., Rebollo,E., Lange,B., Reina,J., Schwarz,H. & Gonzalez, C. (2007). Asterless Is a Centriolar Protein Required for Centrosome Function and Embryo Development in Drosophila. Current Biology 17, 1735-45. IF 10.988

  73. Gonzalez, C. (2007). Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nature Rev Genet 8, 462-472. IF 22.947

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