Marta Bruix
Instituto de Quimica Fisica "Rocasolano"
Serrano 119
Madrid 2006
Tel: (34) 91- 561 - 9400
Fax: (34) 91- 564 - 2431
mbruix@iqfr.csic.es
http://rmn.iqfr.csic.es

Vitae

Degree in Chemistry (University of Barcelona) and Pharmacy (Complutense University of Madrid). Ph. D. awarded in Chemistry, October 1986 (Autonomous University of Madrid). Prof. Marta Bruix is a Senior Researcher of the Spanish Council of Scientific Research, in the Department of Biological Physical Chemistry of the Institute of Physical Chemistry Rocasolano in Madrid (Spain). She is an expert in Nuclear Magnetic Resonance (NMR) Spectroscopy and in its application to protein folding, structure, dynamics and molecular interactions. In 2004 she and others founded the Spanish NMR group (GERMN) of the Spanish Royal Society of Chemistry, and since 2008, she is its President. Since 2008, she is also the coordinator of the Spanish Protein Network.

Scientific interests

We are interested in the physicochemical bases of the biological function and mechanisms which regulates the activities of the macromolecules. Within this field, we apply NMR spectroscopy to determine the three-dimensional structure, dynamics and interactions of different biological systems in solution. Moreover, we implement and optimize new NMR methods. Among the systems studied, it is worth mentioning: hydrosoluble hemolytic pore forming proteins that are also models for the knowledge of protein-membrane interactions; proteins of the ribonuclease family which are studied as models for stability and folding processes, multi heme proteins, and a large variety of allergens from pollen and seeds, and cytotoxic proteins.

Recently, we have started with the structural and physicochemical characterization of intrinsically unfolded proteins, which have gained prominence in recent years due to their importance in regulation, signaling, and other cellular processes needing a subtle and precise molecular control.

Also, we are working on the characterization of biologically active peptides towards the rational design of new compounds with pharmaceutical applications.

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