Isabelle Vernos
Cell and Development Biology program
CRG - Centre Regulació Genómica
Parc de Recerca Biomédica of Barcelona
Dr. Aiguader, 88
08003 Barcelona, Spain
Tel: (34) 93 - 316 - 0277


Isabelle Vernos obtained her postdoctoral at the Welcome CRC Institute, Cambridge, UK in 1989-1992. From 1992-1996 she obtained a postdoctoralat EMBL, Cell Biology Program, Heidelberg, Germany. From 1996-2001 she worked as staff scientist for Cell Biology and Biophysics Program, EMBL, Heidelberg, Germany. From 2001-2005 she was the team leader of the Cell Biology and Biophysics Program, EMBL, Heidelberg, Germany. Since 2005 she is ICREA Research Professor, CRG, Barcelona, Spain.

Scientific interests

Research in my lab is directed at understanding the role of the microtubule network in cell organization and function. To address this question we study various microtubule-associated proteins (molecular motors and MAPs) and their regulators (kinases, phosphatases and the small GTPase Ran during M-phase). One major goal is to unravel how the self-organization of cellular components results in the morphogenesis of dynamic molecular machines. At present we are focusing on one example of self-organization: the assembly of the bipolar spindle in mitosis and meiosis. Our favorite experimental system is the Xenopus egg extract system for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behaviour (Karsenti and Vernos, 2001). We combine it with the use of human tissue culture cells in which we validate some of the results obtained in egg extract.

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