Angel Ramirez Ortiz founded the Bioinformatics Unit of the CBMSO and directed it until is premature death in 2008, aged 41. An international workshop and a special issue of the journal Proteins were dedicated to honoour his memory as one of the most brilliant European researchers in structural biology.

Ángel Ramírez Ortíz
Bioinformatics Unit
Centre for Molecular Biology "Severo Ochoa"
Universidad Autonoma de Madrid
Cantoblanco, 28049 Madrid (Spain)
Tel:: (34) 91- 497-2376 (Office)
Tel:: (34) 91-497-2377 (Lab)


Angel R. Ortiz, started off his research career in Bioinformatics in 1990, as a PhD student at the Department of Pharmacology of the Alcala University, under the supervision of Prof. Federico Gago (1990-1992). Then he moved to the Structural Biology and Biocomputing Department of the European Molecular Biology Laboratory (EMBL) in Heidelberg (Germany), where he was admitted in the selected PhD Program of this Institution. Between 1992 and 1996 he worked at EMBL under the supervision of Dr. Rebecca C. Wade in the development of simplified methods for the fast computation of protein-ligand affinities in congeneric series. Between 1996 and 2000, first as a postdoctoral and later as a Research Assistant at the Department of Molecular Biology of the Scripps Research Institute in San Diego (CA), he worked under the supervision of Prof. Jeffrey Skolnick, pioneering new approaches for protein structure prediction. In June 2000, Dr. Ortiz moves to the Department of Physiology & Biophysics of the Mount Sinai School of Medicine, in New York (NY), where he is appointed as an Assistant Professor (tenure-track). In year 2001 he obtains a position of “Cientifico Titular” (tenured Assistant Professor) at the Spanish National Research Council (CSIC), and as a result he decided to relocate the lab to the Centro de Biologia Molecular “Severo Ochoa” (CBMSO) in Madrid. He was appointed to “Investigador Cientifico” (Associate Professor) in 2003.

Scientific interests

Our research activity centers in the analysis, modeling and prediction of basic biological problems at molecular level. Our main research interests rests in the field of Structural Bioinformatics. The long term interest of the laboratory is in the use of structural information, together with the theory of molecular interactions, to obtain insights that can allow us to design new or better drugs, predict protein structure from sequence, or better understand the process of molecular recognition. Examples of areas of interest to us are the relationship between sequence and structure, understanding the process of structural evolution in proteins, or the study of physical basis of biomolecular recognition and selectivity, among others.

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