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Proteins in the Centrosome

Home page of the Centrosome 3D Consolider collaboration

The Centrosome is a large and complex cellular body that organizes the microtubules and performs vital functions in the regulation of cell cycle, the division and differentiation of animal cells, and is present in simpler form in other eukaryotic cells.
In human cells it is composed by hundreds of proteins, which are highly disordered, coiled-coil and phosphorylated and form a large number of protein-protein interactions. These properties probably contribute to its versatility in space (cell type) and time (development).
We are interested in the evolution of centrosomal proteins and their properties, mainly structural disorder.

Our publications on Centrosomal proteins:

  1. G. S. Nido; R. Méndez; A. Pascual-García; D. Abia and U. Bastolla. Protein disorder in the centrosome correlates with complexity in cell types number. Mol. BioSyst., 2012, DOI: 10.1039/c1mb05199g [Pubmed]

  2. Dos Santos HG, Abia D, Janowski R, Mortuza G, Bertero MG, Boutin M, Guarín N, Méndez-Giráldez R, Nuñez A, Pedrero JG, Redondo P, Sanz M, Speroni S, Teichert F, Bruix M, Carazo JM, González C, Reina J, Valpuesta JM, Vernos I, Zabala JC, Montoya G, Coll M, Bastolla U, Serrano L. Structure and Non-Structure of Centrosomal Proteins. PloS one 8 (5), e62633 [Pubmed]

  3. Bruix M, Treviño MA, García-Mayoral MF, Jiménez MÁ, Bastolla U. Emergence of structure through protein-protein interactions and pH changes in dually predicted coiled-coil and disordered regions of centrosomal proteins. Biochim Biophys Acta. 2014 Oct;1844(10):1808-19. doi: 10.1016/j.bbapap.2014.07.019. Epub 2014 Aug 1. [Pubmed]

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